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VOLUME 9 , ISSUE 6 ( September, 2008 ) > List of Articles


Short-term Effects of a Combination Product Night-time Therapeutic Regimen on Breath Malodor

Robert W. Gerlach, Matthew L. Barker, Svetlana Farrell, Amy Walanski

Citation Information : Gerlach RW, Barker ML, Farrell S, Walanski A. Short-term Effects of a Combination Product Night-time Therapeutic Regimen on Breath Malodor. J Contemp Dent Pract 2008; 9 (6):1-8.

DOI: 10.5005/jcdp-9-6-1

License: CC BY-NC 3.0

Published Online: 01-03-2010

Copyright Statement:  Copyright © 2008; The Author(s).



To evaluate the malodor reduction benefits of a therapeutic night-time oral hygiene regimen that combined antibacterial toothpaste and mouthrinse with an oscillating-rotating rechargeable power toothbrush.

Methods and Materials

An independent clinical trial was conducted using a randomized, negative-controlled, single blind, two treatment, 4-period crossover design. After completing a 1-week acclimation period, subjects were randomly assigned to a treatment sequence consisting of the following two regimens: (1) a night-time regimen of Crest® Pro-Health® Night dentifrice, Crest® Pro-Health® Night rinse, and Oral-B® Vitality™ Precision Clean™ power toothbrush and (2) a control regimen of Crest® Cavity Protection dentifrice and an ADA manual toothbrush. Each treatment period started with an overnight baseline volatile sulfur compounds (VSCs) Halimeter® measurement, followed by twice daily use of the assigned regimen. Post-treatment overnight malodor was assessed at 24 hours. There were 2-day washout periods between treatments. All procedures were repeated with the next assigned regimen, through four crossover periods.


Twenty-five subjects completed the study. Twice daily use of the therapeutic night-time regimen resulted in a significant (p>0.001) 35% reduction of mean VSC levels in the overnight breath compared to the control regimen.


One-day use of a night-time regimen consisting of a therapeutic paste, rinse, and an oscillatingrotating rechargeable power toothbrush provided a 35% reduction in overnight breath malodor compared to regular brushing.

Clinical Significance

Combining a proven therapeutic dentifrice, mouthrinse, and advanced design toothbrush in a single regimen is an efficient means of maximizing breath odor reductions.


Farrell S, Barker ML, Walanski A, Gerlach RW. Short-term Effects of a Combination Product Nighttime Therapeutic Regimen on Breath Malodor. J Contemp Dent Pract 2008 September; (9)6:001-008.

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