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VOLUME 10 , ISSUE 3 ( May, 2009 ) > List of Articles


In vitro Pharmacodynamic Activities of Root Canal Sealers on Enterococcus faecalis

Özgür Er, Burak Sagsen, Duygu Esel, Gülhan Yagmur, Yasemin Altintop

Citation Information : Er Ö, Sagsen B, Esel D, Yagmur G, Altintop Y. In vitro Pharmacodynamic Activities of Root Canal Sealers on Enterococcus faecalis. J Contemp Dent Pract 2009; 10 (3):35-42.

DOI: 10.5005/jcdp-10-3-35

License: CC BY-NC 3.0

Published Online: 01-06-2012

Copyright Statement:  Copyright © 2009; The Author(s).



The aim of this study was to evaluate the antimicrobial efficiency of different root canal sealers on Enterococcus faecalis (E. Faecalis) at different time intervals.

Methods and Materials

All sealers used were mixed according to the manufacturers’ instructions then 75 mg of each sealer was added to different sterile tubes and evaluated at 20 minutes, 24 hours, 7 days, and 30 days. A time-kill assay (TKA) was used to determine the antimicrobial efficiency of the sealers.


AH Plus and MCS were found to be bactericidal at 20 minutes and 24 hours, but only MCS was bactericidal at the seventh and thirtieth days. Epiphany and Sealapex were found to be bacteriostatic at the seventh and thirtieth days but indifferent at 20 minutes and 24-hours. MCS and AH Plus were both found to be bactericidal in freshly mixed samples, but only MCS was bactericidal at longer time periods. Epiphany Sealer and Sealapex were found to be bacteriostatic at longer time periods but indifferent at 20 minutes and 24 hours.


The antibacterial effect of MCS was greater than the other sealers evaluated.

Clinical Significance

Sealers containing eugenol and epoxy resin might be preferable due to their antibacterial effect.


Sagsen B, Er O, Esel D, Yagmur G, Altintop Y. In vitro Pharmacodynamic Activities of Root Canal Sealers on Enterococcus faecalis. J Contemp Dent Pract 2009 May; (10)3:035-042.

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