The Journal of Contemporary Dental Practice

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 10 , ISSUE 6 ( November, 2009 ) > List of Articles


Aggressive Pregnancy Tumor Mimicking A Malignant Neoplasm: A Case Report

Khansa Ababneh, Taiseer Al-Khateeb

Citation Information : Ababneh K, Al-Khateeb T. Aggressive Pregnancy Tumor Mimicking A Malignant Neoplasm: A Case Report. J Contemp Dent Pract 2009; 10 (6):72-78.

DOI: 10.5005/jcdp-10-6-72

License: CC BY-NC 3.0

Published Online: 01-08-2015

Copyright Statement:  Copyright © 2009; The Author(s).



The aim of this report is to present the management of an aggressive, highly proliferative pregnancy tumor with clinical and radiographic characteristics highly suggestive of a malignant neoplasm.


Pregnancy tumor is a benign hyperplastic gingival lesion occurring during pregnancy that is indistinguishable from a pyogenic granuloma arising in nonpregnant females, or in males. The lesion usually grows over a few months and tends to bleed.

Case Description

A 28-year-old woman at four months of gestation was referred for a massive gingival swelling (5.5 cm in greatest diameter) on the mandibular left side. The lesion was painful and continued to grow very rapidly over a threeweek period, with spontaneous bleeding, and it interfered with speech and mastication. Advanced alveolar bone loss also was found beneath the lesion. A malignant process was suspected, and an incisional biopsy revealed a pregnancy tumor. The lesion was excised under general anesthesia during the pregnancy with no untoward reactions.


Pregnancy tumor represents an important differential diagnosis of oral masses and can behave in a very aggressive fashion, mimicking a malignant tumor.

Clinical Significance

This lesion should always be included in the differential diagnosis of soft tissue masses in a pregnant woman even if the lesion is clinically very aggressive. It is acceptable practice to excise aggressive variants of this lesion during pregnancy to avoid distressing side effects.


Ababneh K, Al-Khateeb T. Aggressive Pregnancy Tumor Mimicking a Malignant Neoplasm: A Case Report. J Contemp Dent Pract [Internet]. 2009 Nov; 10(6):072-078. Available from: volume10-issue6-ababneh.

PDF Share
  1. [Hyperplastic gingival lesions in pregnancy. I. Epidemiology, pathology and clinical aspects]. Minerva Stomatol. 1998; 47(4):159–67.
  2. The late development of oral pyogenic granuloma as a complication of pregnancy: a case report. Compend Contin Educ Dent. 1996; 17(2):192–8.
  3. Pregnancy tumor in a 16-year-old: case report and treatment considerations. J Clin Pediatr Dent. 1992; 16(3):217–8.
  4. Hyperplastic lesions of the gingiva and alveolar mucosa. A study of 175 cases. Acta Odontol Scand. 1983; 41(2):75–86.
  5. Pyogenic granuloma—clinical features, incidence, histology, and result of treatment: report of 242 cases. J Oral Surg. 1966; 24(5):391–8.
  6. Pregnancy-associated pyogenic granuloma of the lip: successful management using cryotherapy. J Gt Houst Dent Soc. 1996; 67(7):18–9.
  7. Management considerations for the granuloma of pregnancy. Plast Reconstr Surg. 1995; 95(6):1045–50.
  8. Common oral manifestations during pregnancy: a review. Obstet Gynecol Surv. 2003; 58(9):624–8.
  9. Effect of pregnancy on periodontal and dental health. Acta Odontol Scand. 2002; 60(5):257–64.
  10. Recurrent gigantic pyogenic granuloma disturbing speech and mastication: a case report and literature review. Ann Acad Med Singapore. 1998; 27(2):258–61.
  11. Identification and semiquantification of estrogen and progesterone receptors in pyogenic granulomas of pregnancy. Oral Surg Oral Med Oral Pathol. 1994; 78(6):755–60.
  12. Oral pyogenic granuloma in Jordanians: a retrospective analysis of 108 cases. J Oral Maxillofac Surg. 2003; 61(11):1285–8.
  13. Pregnancy tumor: an analysis. Oral Surg Oral Med Oral Pathol. 1991; 72(2):196-9.
  14. Swellings and tumors of the oral cavity and face. In: Silverman S Jr, Eversole RL, Truelove EL, editors. Essentials of oral medicine. Ontario: BC Decker Inc;. 2002. p. 228-44.
  15. Benign ulceroproliferative lesion in the mandibular gingivae of a 42-year-old Asian female. J Oral Maxillofac Surg. 2008; 66(7):1455-60.
  16. Common benign oral soft tissue masses. Dent Clin North Am. 2005; 49(1):223-40.
  17. Peripheral ossifying fibroma. Report of a case and review of the literature. Med Oral. 2001; 6(2):135-41.
  18. Growth potential of peripheral ossifying fibroma. J Clin Periodontol. 1987;14(9):551–4.
  19. The detection and comparison of angiogenesis-associated factors in pyogenic granuloma by immunohistochemistry. J Periodontol. 2000; 71(5):701-9.
  20. Severe bleeding from a pregnancy tumor. A case report. J Reprod Med. 1997; 42(6):359-62.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.