Clinical Trials with Oncolytic Viruses: Current and Future Prospects
[Year:2015] [Month:August] [Volume:16] [Number:8] [Pages:1] [Pages No:0 - 0]
DOI: 10.5005/jcdp-16-8-i | Open Access | How to cite |
[Year:2015] [Month:August] [Volume:16] [Number:8] [Pages:6] [Pages No:613 - 618]
DOI: 10.5005/jp-journals-10024-1730 | Open Access | How to cite |
Abstract
The purpose of the current study was to compare the fracture resistance and mode of failure of zirconia and titanium abutments with different diameters. Fourteen groups of abutments including prefabricated zirconia, copy-milled zirconia and titanium abutments of an implant system (XiVE, Dentsply) were prepared in different diameters. An increasing vertical load was applied to each specimen until failure occurred. Fracture resistance was measured in each group using the universal testing machine. Moreover, the failure modes were studied and categorized as abutment screw fracture, connection area fracture, abutment body fracture, abutment body distortion, screw distortion and connection area distortion. Groups were statistically compared using univariate and post-hoc tests. The level of statistical significance was set at 5%. Fabrication method (p = 0.03) and diameter (p < 0.001) had significant effect on the fracture resistance of abutments. Fracture resistance of abutments with 5.5 mm diameter was higher than other diameters (p < 0.001). The observed modes of failure were dependent on the abutment material as well. All of the prefabricated titanium abutments fractured within the abutment screw. Abutment screw distortion, connection area fracture, and abutment body fracture were the common failure type in other groups. Diameter had a significant effect on fracture resistance of implant abutments, as abutments with greater diameters were more resistant to static loads. Copy-milled abutments showed lower fracture resistance as compared to other experimental groups. Although zirconia abutments have received great popularity among clinicians and even patients selecting them for narrow implants should be with caution. Shabanpour R, Mousavi N, Ghodsi S, Alikhasi M. Comparative Evaluation of Fracture Resistance and Mode of Failure of Zirconia and Titanium Abutments with Different Diameters. J Contemp Dent Pract 2015;16(8):613-618.
[Year:2015] [Month:August] [Volume:16] [Number:8] [Pages:5] [Pages No:619 - 623]
DOI: 10.5005/jp-journals-10024-1731 | Open Access | How to cite |
Abstract
To compare the antimicrobial activity of the chemical substances—70% isopropyl alcohol, 2% glutaraldehyde (GTA) and 0.25% peracetic acid (PAA) in disinfecting orthodontic pliers contaminated Distal end cutter pliers were divided into five groups: group 1 (negative control—sterilized pliers), group 2 (positive control—sterilized plier, subsequently contaminated), group 3 (disinfected with 70% isopropyl alcohol, friction method), group 4 (disinfected with 2% GTA, immersion method for 30 minutes), group 5 (disinfected with 0.25% peracetic acid (PAA), immersion method for 10 minutes). After the pliers were treated with one disinfectant and submitted to microbiological evaluation (by counting colony forming units), they were submitted to the same cleansing, sterilizing and contaminating processes, and were used in the following groups (crossover and washout study). The two-factor analysis of variance (ANOVA) test, followed by the Tukey test, was used to compare the groups. The results showed that there was no statistically significant difference between the three tested disinfectants. Although there were no statistically significant differences between the disinfectants, the chemical agents 2% glutaraldehyde and 0.25% PAA were effective in inhibiting the growth of the three microorganisms tested; however, 70% isopropyl alcohol was unable to completely eliminate The chemical substances 2% glutaraldehyde and 0.25% PAA completely eliminated the microorganisms tested. Carvalho MRA, dos Santos da Silva MA, de Sousa Brito CAR, Campelo V, Kuga MC, Tonetto MR, De Jesus Tavarez RR, Bandéca MC, Pinzan-Vercelino CRM. Comparison of Antimicrobial Activity between Chemical Disinfectants on Contaminated Orthodontic Pliers. J Contemp Dent Pract 2015;16(8):619-623.
[Year:2015] [Month:August] [Volume:16] [Number:8] [Pages:6] [Pages No:624 - 629]
DOI: 10.5005/jp-journals-10024-1732 | Open Access | How to cite |
Abstract
To evaluate pH and antibacterial activity of pastes with calcium hydroxide [Ca(OH)2] and zinc oxide (ZnO) microparticles (micro) or nanoparticles (nano) and association with 0.4% chlorhexidine against The following pastes were analyzed: Ca(OH)2/ZnO micro, (2) Ca(OH)2/ZnO nano, (3) Ca(OH)2/ ZnO micro + 0.4% chlorhexidine, (4) Ca(OH)2/ZnO nano + 0.4% chlorhexidine. Antibacterial activity against Calcium hydroxide and zinc oxide nano, and the pastes with 0.4% chlorhexidine were more effective in agar diffusion test. In the direct contact test, the pastes with chlorhexidine showed the highest effect after 30 seconds. All pastes eliminated It was concluded that calcium hydroxide and zinc oxide nanoparticles promoted greater initial alkalinization. The antimicrobial activity of the pastes against Although nanoparticles of calcium hydroxide and zinc oxide promoted antibacterial effect, the activity against Aguiar AS, Guerreiro-Tanomaru JM, Faria G, Leonardo RT, Tanomaru-Filho M. Antimicrobial Activity and pH of Calcium Hydroxide and Zinc Oxide Nanoparticles Intracanal Medication and Association with Chlorhexidine. J Contemp Dent Pract 2015;16(8):624-629.
[Year:2015] [Month:August] [Volume:16] [Number:8] [Pages:8] [Pages No:630 - 637]
DOI: 10.5005/jp-journals-10024-1733 | Open Access | How to cite |
Abstract
To evaluate the bone thickness and density in the lower incisors’ region in orthodontically untreated adults, and to examine any possible relationship between thickness and density in different skeletal patterns using cone-beam computed tomography (CBCT). The CBCT records of 48 patients were obtained from the archive of orthodontic department comprising three groups of malocclusion (class I, II and III) with 16 patients in each group. Using OnDemand 3D® software, sagittal sections were made for each lower incisor. Thicknesses and densities were measured at three levels of the root (cervical, middle and apical regions) from the labial and lingual sides. Accuracy and reliability tests were undertaken to assess the intraobserver reliability and to detect systematic error. Pearson correlation coefficients were calculated and one-way analysis of variance (ANOVA) was employed to detect significant differences among the three groups of skeletal malocclusion. Apical buccal thickness (ABT) in the four incisors was higher in class II and I patients than in class III patients (p < 0.05). There were significant differences between buccal and lingual surfaces at the apical and middle regions only in class II and III patients. Statistical differences were found between class I and II patients for the cervical buccal density (CBD) and between class II and III patients for apical buccal density (ABD). Relationship between bone thickness and density values ranged from strong at the cervical regions to weak at the apical regions. Sagittal skeletal patterns affect apical bone thickness and density at buccal surfaces of the four lower incisors’ roots. Alveolar bone thickness and density increased from the cervical to the apical regions. Al-Masri MMN, Ajaj MA, Hajeer MY, Al-Eed MS. Evaluation of Bone Thickness and Density in the Lower Incisors’ Region in Adults with Different Types of Skeletal Malocclusion using Cone-beam Computed Tomography. J Contemp Dent Pract 2015;16(8):630-637.
[Year:2015] [Month:August] [Volume:16] [Number:8] [Pages:5] [Pages No:638 - 642]
DOI: 10.5005/jp-journals-10024-1734 | Open Access | How to cite |
Abstract
This Twenty molars presenting natural occlusal dentin caries lesions (10 primary–PriC and 10 permanent– PermC; control group), and 20 sound molars (10 primary – PripH and 10 permanent–PermpH; experimental group), were selected. Occlusal cavities were prepared in teeth of the experimental group that were submitted to pH-cycling for 14 days to simulate caries-affected dentin. All specimens were longitudinally sectioned and prepared in order to obtain Knoop microhardness values from 15 to 250 ìm depth, starting in bottom of center of natural lesions or cavities. The microhardness (KHN) data were submitted to three-way repeated measures analysis of variance (ANOVA) and Tukey's tests (α = 0.05). Considering all depths, there was no statistically significant differences (p > 0.05) between the mineral loss of the control (PriC = 30.9 ± 6.4 and PermC = 40.8 ± 8.6) and experimental (PripH = 27.3 ± 11.1 and PermpH = 35.5 ± 14.0) groups, neither between primary and permanent teeth. The mineral loss of the artificially-created cariesaffected dentin is similar to that from naturally developed dentin caries lesions. The pH-cycling model may be a suitable method to simulate caries-affected dentin in both permanent and primary teeth. Lenzi TL, Soares FZM, Tedesco TK, de Oliveira Rocha R. Is It Possible to induce Artificial Caries-affected Dentin using the Same Protocol to Primary and Permanent Teeth? J Contemp Dent Pract 2015;16(8):638-642.
[Year:2015] [Month:August] [Volume:16] [Number:8] [Pages:5] [Pages No:643 - 647]
DOI: 10.5005/jp-journals-10024-1735 | Open Access | How to cite |
Abstract
The aim of this Patients with premolars needing class II type resin composite restorations involving the marginal ridge were selected. Thirty premolars were selected and randomly divided into three groups (n = 10 each) to receive restorations using different matrix systems: group 1: metal matrix coupled to a carrier matrix and wood wedge (G1-MMW); group 2: sectioned and precontoured metal matrix and elastic wedge (G2-SME); and group 3: a polyester strip and reflective wedge (G3-PMR). After the restorative procedure, bitewing radiographs were performed and analyzed by three calibrated professionals. The quality of the proximal contact and marginal adaptation of the proximal surfaces was classified as either correct or incorrect (undercontour/overcontour). The Pearson Chi-square statistical test (α = 5%) revealed a statistically difference between frequencies of correct and incorrect restorations (α2 = 6.787, p < 0.05). The group G2 SME produced a higher frequency of correct proximal contours (90%), while G1-MMW and G3-PMR had a ratio of 40% correct and 60% incorrect contours respectively. None of the matrix systems was able to prevent the formation of incorrect proximal contours; however, the sectioned and precontoured metal matrix/elastic wedge configuration provided better results as compared to the other groups. Gomes IA, Filho EMM, Mariz DCBR, Borges AH, Tonetto MR, Firoozmand LM, Kuga CM, De Jesus RRT, Bandéca MC.
[Year:2015] [Month:August] [Volume:16] [Number:8] [Pages:9] [Pages No:648 - 656]
DOI: 10.5005/jp-journals-10024-1736 | Open Access | How to cite |
Abstract
To assess intra- and interobserver agreement when evaluating maxillary impacted canines using cone beam computed tomography (CBCT) and two-dimensional (2D) images through a panel of orthodontically trained observers. An adult skull with permanent dentition was employed to perform 15 simulated maxillary canine impactions. Two sets of 2D and three-dimensional (3D) radiographic images were acquired. A panel of assessors including 11 PhD and MSc postgraduate orthodontic students evaluated maxillary impacted canines using a standard questionnaire with 11 categorical variables. Kappa (K) statistics as well as Krippendorff's alpha (α) coefficients were used for the analysis of reliability. A high level of intraobserver agreement was found for both the CBCT- and 2D-based interpretations. The 11 observers demonstrated a higher interobserver agreement for the CBCTbased interpretations than that of the 2D-based interpretations (α = 0.68 and 0.38 respectively). The employed 3D classifications canines was found to be reliable among observers on CBCT images for the labiopalatal position (K = 0.87), mesiodistal position, vertical position, labiopalatal inclination and mesiodistal inclination (α = 0.95, 0.83, 0.84 and 0.92 respectively). The 2D-based interpretations were not in agreement among the 11 observers, except for the mesiodistal position (α = 0.88) and mesiodistal inclination (α = 0.88). The intraobserver agreement was high for both the 2D- and the CBCT-based interpretations. The interobserver agreement for the CBCT-based interpretations was remarkably higher than that of the 2D-based interpretations. The utilized CBCT-based 3D classifications for the location and inclination of maxillary impacted canines were found reliable among observers. Al-Homsi HK, Hajeer MY. An Evaluation of Inter- and Intraobserver Reliability of Cone-beam Computed Tomography- and Two Dimensional-based Interpretations of Maxillary Canine Impactions using a Panel of Orthodontically Trained Observers. J Contemp Dent Pract 2015;16(8):648-656.
[Year:2015] [Month:August] [Volume:16] [Number:8] [Pages:8] [Pages No:657 - 664]
DOI: 10.5005/jp-journals-10024-1737 | Open Access | How to cite |
Abstract
To compare the efficacy of calcium hydroxide powder mixed with 0.2% chlorhexidine digluconate or mixed with normal saline as intracanal medicament in the treatment of apical periodontitis. Subjects were 55 in number aged 17 to 60 years. Two-visit conventional root canal treatment was performed on 70 teeth. The teeth were divided by randomization (balloting) into two groups: control group and experimental group, each with 35 teeth treated with calcium hydroxide mixed with normal saline or with 0.2% chlorhexidine digluconate as intracanal medicament respectively. All treated teeth were evaluated clinically and radiographically for signs and symptom of periapical infection at specified periods postoperatively. Overall efficacy of medicament was rated based on quality guidelines for endodontic treatment by the European Society of Endodontology 2006. A postoperative favorable outcome of 97.1% in the control group and 94.3% in the experimental group was observed at 6-month review. This difference was not statistically significant (p > 0.05). The use of normal saline or 0.2% chlorhexidine digluconate to mix calcium hydroxide used as intracanal medicament during endodontic treatment resulted in high postoperative favorable outcomes. Efficacy of 0.2% chlorhexidine digluconate as a vehicle for mixing calcium hydroxide as an intracanal medicament in the treatment of apical periodontitis is compa rable to the efficacy of calcium hydroxide mixed with normal saline. Menakaya IN, Adegbulugbe IC, Oderinu OH, Shaba OP. The Efficacy of Calcium Hydroxide Powder mixed with 0.2% Chlorhexidine Digluconate or mixed with normal Saline as Intracanal Medicament in the Treatment of Apical Periodontitis. J Contemp Dent Pract 2015;16(8):657-664.
[Year:2015] [Month:August] [Volume:16] [Number:8] [Pages:9] [Pages No:665 - 673]
DOI: 10.5005/jp-journals-10024-1738 | Open Access | How to cite |
Abstract
This study assessed the biocorrosive capacity of two bacteria: In the first stage, the corrosive potential of the artificial saliva medium (ASM), modified Postgate E medium (MPEM), 2.5 % sodium hypochlorite (NaOCl) solution and white medium (WM), without the inoculation of bacteria was assessed by immersion assays. In the second stage, test samples were inoculated with the two species of sulphur-reducing bacteria (SRB) on ASM and modified artificial saliva medium (MASM). In the third stage, test samples were inoculated with the same species on MPEM, ASM and MASM. All test samples were viewed under an infinite focus Alicona microscope. No test sample became corroded when immersed only in media, without bacteria. With the exception of one test sample between those inoculated with bacteria in ASM and MASM, there was no evidence of corrosion. Fifty percent of the test samples demonstrated a greater intensity of biocorrosion when compared with the initial assays. This study describes the initial development of a biopharmaceutical to facilitate the removal of endodontic file fragments from root canals, which can be successfully implicated in endodontic therapy in order to avoiding parendodontic surgery or even tooth loss in such events. Heggendorn FL, Gonçalves LS, Dias EP, de Oliveira Freitas Lione V, Lutterbach MTS. Biocorrosion of Endodontic Files through the Action of Two Species of Sulfatereducing Bacteria:
Effectiveness of Oral Antiseptics on Tooth Biofilm: A Study in vivo
[Year:2015] [Month:August] [Volume:16] [Number:8] [Pages:5] [Pages No:674 - 678]
DOI: 10.5005/jp-journals-10024-1739 | Open Access | How to cite |
Abstract
To evaluate the effectiveness of five different mouthwashes through measurement of the plaque index. Fifty subjects took part in this blind study, randomized into blocks of five groups according to the active ingredient of the mouthwash: CHX group (0.12% chlorhexidine gluconate), essential oils (EO) group, cetylpyridinium chloride (CPC) group, Tri group (triclosan) and There was a significant reduction in the mean plaque index during the period of evaluation (p < 0.01), and the reduction during the period of evaluation was different between mouthwashes (p < 0.01). The reduction in the plaque index at the end of 21 days was, in decreasing order, CHX > EO > CPC > Tri > HV. The reduction in the plaque index during the period of evaluation was different between the types of mouthwash. The mouthwash containing the active ingredient chlorhexidine was the most effective, followed by the essential oil, cetylpyridinium chloride, triclosan and Junior Mouchrek JCE, Nunes LHAC, Arruda CS, Rizzi CC, Mouchrek AQS, Tavarez RRJ, Tonetto MR, Bandeca MC, Maia Filho EM. Effectiveness of Oral Antiseptics on Tooth Biofilm: A Study
The Effects of Ionizing Radiation on the Oral Cavity
[Year:2015] [Month:August] [Volume:16] [Number:8] [Pages:9] [Pages No:679 - 687]
DOI: 10.5005/jp-journals-10024-1740 | Open Access | How to cite |
Abstract
The aim of this study is to present a literature review on the effects of the ionizing radiation from radiotherapy treatment on dental tissues. Among the effects of increasing global life expectancy and longevity of the teeth in the oral cavity, increasing rates of neoplastic diseases have been observed. One of the important treatment modalities for head and neck neoplastic diseases is radiotherapy, which uses ionizing radiation as the main mechanism of action. Therefore, it is essential for dentists to be aware of the changes in oral and dental tissues caused by ionizing radiation, and to develop treatment and prevention strategies. In general, there is still controversy about the effects of ionizing radiation on dental structures. However, qualitative and quantitative changes in saliva and oral microbiota, presence of oral mucositis and radiation-related caries are expected, as they represent the well-known side effects of treatment with ionizing radiation. Points that still remain unclear are the effects of radiotherapy on enamel and dentin, and on their mechanisms of bonding to contemporary adhesive materials. Ionizing radiation has shown important interaction with organic tissues, since more deleterious effects have been shown on the oral mucosa, salivary glands and dentin, than on enamel. With the increasing number of patients with cancer seeking dental treatment before and after head and neck radiotherapy, it is important for dentists to be aware of the effects of ionizing radiation on the oral cavity. de Barros da Cunha SR, Ramos PAM, Nesrallah ACA, Parahyba CJ, Fregnani ER, Aranha ACC. The Effects of Ionizing Radiation on the Oral Cavity. J Contemp Dent Pract 2015;16(8):679-687.
[Year:2015] [Month:August] [Volume:16] [Number:8] [Pages:4] [Pages No:688 - 691]
DOI: 10.5005/jp-journals-10024-1741 | Open Access | How to cite |
Abstract
Increase in adult orthodontic patients has increased the challenges faced by orthodontists, as they often present themselves with a varying degree of dental and periodontal compromise, in which the entire orthodontic treatment planning will revolve around maintenance and augmentation of supporting apparatus. One of the many factors to be considered during treating an adult patient is the height of alveolar bone and its effect on center of resistance (CRes). Eight 3D analytical models of upper central incisor were designed using ‘Solid Works Office Premium’. The models were subjected to 3 and 6 mm bone loss along all four surfaces, i.e. labial, lingual, mesial and distal. One Newton of retraction force was applied on labial surface of tooth on model number 1, 2, 5 and 6 and 1N of distalization force was applied to model number 3, 4, 7 and 8. The relative location of the CRes to the total root length was taken as 41.8% of total root length from the root apex. The ANSYS software was used to evaluate the change in CRes on all the models. It was observed that CRes shifted apically from its relative location (41.8% from apex); however, this shift was clinically insignificant. Minimum deflection of CRes, 0.0122 mm, was seen when a distalization force was applied on model with 6 mm bone loss on distal surface, while maximum deflection of 0.0245 mm was seen when retraction force was applied on model with 6 mm bone loss on labial surface. The resultant displacement in position of center of resistance is negligible; hence, there is no need of changing biomechanics during orthodontic treatment for a tooth with three wall infrabony defects. However, it is necessary to further study other infrabony defects like two wall or one wall defect, and their effect on position of CRes. Chachada AD, Hazarey PV, Aley MS, Atram HK, Kharche A. Effect of Three-wall Bony Defect along Various Root Surfaces on Position of Center of Resistance: A 3D Finite Element Analysis. J Contemp Dent Pract 2015;16(8): 688-691.
Genotoxicity of Endodontic Materials: A Critical Review
[Year:2015] [Month:August] [Volume:16] [Number:8] [Pages:5] [Pages No:692 - 696]
DOI: 10.5005/jp-journals-10024-1742 | Open Access | How to cite |
Abstract
Mohammadi Z, Shalavi S, Jafarzadeh H, Bhandi S, Patil S. Genotoxicity of Endodontic Materials: A Critical Review. J Contemp Dent Pract 2015;16(8):692-696.
An Intraoperative Site-specific Bone Density Device: A Pilot Test Case
[Year:2015] [Month:August] [Volume:16] [Number:8] [Pages:7] [Pages No:697 - 703]
DOI: 10.5005/jp-journals-10024-1743 | Open Access | How to cite |
Abstract
This paper reports a case of all-on-four rehabilitation where bone density at implant sites was assessed both through preoperative computed tomographic (CT) scans and using a micromotor working as an intraoperative bone density measurement device. Implant-supported rehabilitation is a predictable treatment option for tooth replacement whose success depends on the clinician's experience, the implant characteristics and location and patient-related factors. Among the latter, bone density is a determinant for the achievement of primary implant stability and, eventually, for implant success. The ability to measure bone density at the placement site before implant insertion could be important in the clinical setting. A patient complaining of masticatory impairment was presented with a plan calling for extraction of all her compromised teeth, followed by implant rehabilitation. A week before surgery, she underwent CT examination, and the bone density on the CT scans was measured. When the implant osteotomies were created, the bone density was again measured with a micromotor endowed with an instantaneous torque-measuring system. The implant placement protocols were adapted for each implant, according to the intraoperative measurements, and the patient was rehabilitated following an all-on-four immediate loading protocol. The bone density device provided valuable information beyond that obtained from CT scans, allowing for site-specific, intraoperative assessment of bone density immediately before implant placement and an estimation of primary stability just after implant insertion. Measuring jaw-bone density could help clinicians to select implant-placement protocols and loading strategies based on site-specific bone feature Arosio P, Moschioni M, Banfi LM, Di Stefano DA. An Intraoperative Site-specific Bone Density Device: A Pilot Test Case. J Contemp Dent Pract 2015;16(8): 697-703.
[Year:2015] [Month:August] [Volume:16] [Number:8] [Pages:4] [Pages No:704 - 707]
DOI: 10.5005/jp-journals-10024-1744 | Open Access | How to cite |
Abstract
The aim of this report is to present the management of the maxillary deformity and subsequent implant therapy of a case with β-thalassemia major. β-thalassemia is a hematologic disorder that results from the abnormality of the β-globulin chain synthesis. The best known thalassemia-induced dentofacial problem is the maxillary enlargement, and this undesirable growth of maxilla affects not only the facial esthetics but also dental occlusion, and leads to functional deficiency. A 16-year-old female patient with â-thalassemia major was referred with the complaints of severe facial deformity and malocclusion, resulting in psychosocial and functional problems for her. The dentofacial deformity was characterized by an excessive premaxillary growth both in sagittal and vertical planes. Anterior maxillary osteotomy was performed with bilateral canines extraction, and dental implants were inserted to the canine regions, following bone healing. Postoperative course was free of problems with the crown restorations in function. Recurrence has not been occurred at 6 years follow-up. With maintaining hemoglobin level over 10 gm/dl, correction of maxillary defects is stable for long-term in â-thalassemia major patient. Implant application to these patients may lead to unforeseeable results. Although having some difficulties, such as overbleeding and stability problems, maxillary enlargement can be treated by segmental osteotomies successfully in β-thalassemia major patient. Implant failure frequency may be higher, but many other studies are needed for determining implant survival rate in β-thalassemia major patients. Pektas ZO, Cubuk S, Kircelli B, Uckan S. Management of Maxillary Deformity with Segmental Osteotomy followed by Implant Insertion in β-Thalassemia Major Patient. J Contemp Dent Pract 2015;16(8):704-707.